AB0315 ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS APPEAR TO HAVE IMPAIRED QUADRICEPS MUSCLE MORPHOLOGY ASSESSED BY ULTRASOUND AND MUSCLE STRENGTH IMPAIRED OVER TIME: A COHORT STUDY

Background Rheumatoid arthritis (RA) patients usually present extra-articular manifestations [1], which affect muscle strength, mass and physical functional [2]. There are several methods to assess and, among these methods, ultrasound (MU) has been suggested as an alternative morphology [3]. Objectives [1] To the MU of quadriceps verify changes over time (1-year) in thickness pennation angle RA patients; [2] clinical features, patients. Methods patients, age ≥18years who met 2010 American College Rheumatology criteria were included. Morphological parameters consisted rectus femoris (RF), vastus intermedius (VI) lateralis (VL). activity was measured by 28-joint disease score (DAS28) assessed C-reactive protein (CRP), strength handgrip, health assessment questionnaire (HAQ) timed-up-and-go (TUG) test. The paired samples Wilcoxon test used compare variables between baseline 1-year assessments. significance level set at p≤0.05 for all analyzes. Results At baseline, 155 with median 60.00 (52.00-65.00) years old, duration 11.00 (6.00-20.00) DAS28-CRP 2.77 (2.02-3.76) Until moment, twenty-two completed follow-up. Among re-evaluated there a decrease VL (-11%) VI (-13%) angles muscle, handgrip (-36%) after 1-year. On other hand, no observed thickness, RF angle, DAS28-CRP, HAQ, TUG (p>0.05; table 1). Conclusion These preliminary observations indicate that established have impaired quality (pennation angles) time. However, it is necessary complete remainder reassessments confirm findings, besides verifying associations parameters. References Summers GD, et al. (Oxford). 2008;(4) 1124–31. Dos Santos LP, Diagnostics (Basel). 2021 29;11(11):2014. [3] Cruz-Jentoft AJ, Age Ageing. 2019;48:16–31. Table 1. Changes morphological parameters, [n] 1-year,[n] Δ,[n] p value Muscle (cm) Rectus 1.01 (0.81–1.31), [154] 0.89 (0.59–1.34), [22] -0.07 (-0.22–0.13), 0.485 Vastus 1.06 (0.88–1.32), 0.95 (0.76–1.07), -0.02 (-0.06–0.01), 0.115 1.47 (1.24–1.78), [155] 1.36 (1.15–1.51), (-0.23–0.08), 0.230 Pennation (º) 9.67 (7.80–11.48), 8.51 (7.57–9.50), 0.03 (-1.79–0.51), 0.338 9.08 (7.17–10.63), 7.56 (6.86–9.80), -0.59 (-1.22–0.07), 0.013* 13.09 (11.10–14.58), 11.89 (11.26–13.64), -1.23 (-2.37– -0.03), 0.003* Handgrip (kg) 18.00 (10.00–24.00), 9.00 (3.75–14.25), -2.50 (-11.25–2.25), 0.049* (2.02–3.76), 2.43 (2.03–3.39), -0.31 (-1,76–0.31), 0.088 HAQ (score) 1.00 (0.50–1.63), [138] 1.13 (0.60–1.47), 0.12 (-0.44–0.44), [13] 0.944 (s) 9.45 (7.33–10.34), [137] 8.00 (7.22-8.80), -0.49 (-1.15–0.92), [18] 0.514 Abbreviation: Δ, Delta (1year - baseline); CRP; Health questionnaire; TUG, Timed-up-and-go; cm, centimeters; º, degrees; kg, kilograms; s, seconds. *p<0.05. data shown (interquartile range, IQR). Acknowledgements We thank Foundation Research Support Rio Grande do Sul State (Fundação de Amparo à Pesquisa Estado Sul-FAPERGS), Coordination Improvement Higher Level Personnel (Coordenação Aperfeiçoamento Pessoal Nível Superior—CAPES) institution, Events Incentive Fund (Fundo Incentivo e Eventos-FIPE) HCPA Technological Development (Conselho Nacional Desenvolvimento Científico Tecnológico—CNPq). Disclosure Interests None Declared.